An adjuvant is a substance that enhances and helps the ability of an antigen to stimulate the immune system. An antigen alone does not stimulate a significant response. Less vaccine antigen (inactive bacteria, virus or toxin) is needed when paired with the right adjuvant.
Aluminum hydroxide gel VAC grades for adsorption (Pseudo-Boehmite form) are used as an adjuvant in human and animal vaccines. It is used to bind negatively charged antigens.
Its functionality is to adsorb a large range of proteins and inactivated viruses. At pH of preparation of vaccines around 5-7, Pseudo-Boehmite gels have the property to:
Adsorbent properties are related to surface area and surface groups, the hydroxyl groups can
Aluminium Hydroxide Adjuvants surface charge is pH dependant.
Our principal SPIPharma offers the ability to customize the VAC grades to optimize the performance with your antigen or match your current adjuvant.
Human applications for vaccines, blood fractionation and systemic allergen immunotherapy
Example vaccines:
For blood fractionation, the Aluminum based adjuvant is used to remove certain serum components during a purification process due to its protein adsorption capabilities.
Today, most subcutaneous allergen immunotherapy is performed with Aluminum, Al(OH)3, as adjuvant.
Veterinary applications for vaccines for livestock and companion animals (production from inactivated virus)