Effer-Soda® is a highly stable mixture of surface modified sodium carbonate and sodium bicarbonate powder developed for use in pharmaceutical and nutraceutical application. Effervescent delivery systems can provide a number of advantages, including possible improved bioavailability and faster on set of therapeutic action.
These convenient dosage forms are fast dissolving, highly soluble, and stable. For example, effervescent tablets provide the ease of carrying a tablet while at the same time giving the bioavailability of ingesting a solution. For these reasons, the delivery form is popular for many pharmaceutical products such as antacids, analgesic, or cough / cold formulations and nutraceutical product such as multi-vitamin and calcium supplement formulations.
Sodium bicarbonate is a primary ingredient in effervescent tablets and powders. Together with an acid, such as citric acid or tartaric acid, sodium bicarbonate reacts in the presence of water to the produce carbon dioxide (CO2). Consequently, the major disadvantage of sodium bicarbonate is that, in the presence of minute amounts of moisture and acid, it immediately effervesces.
This reactivity can lead to formulation instability and premature effervescence on stability and storage. Also, additional steps to pre-dry the powder along with special equipment and processing conditions are required during manufacture in order to avoid premature effervescence.
Effer-Soda® effectively protects against premature effervescence by reducing the moisture sensitivity of the formulation. This is accomplished by modifying the surface of the sodium bicarbonate with a desiccant skin of sodium carbonate that surrounds the sodium bicarbonate core.
This desiccant skin acts to protect the faster reducing sodium bicarbonate core by absorbing small amounts of moisture and thus reducing the possibility of premature effervescence in formulations. However, in the presence of large amounts of water, Effer-Soda®s readily dissolves and provides rapid effervescence.